Esophageal tissue engineering: from bench to bedside

17 August 2018

For various esophageal diseases, the search for alternative techniques for tissue repair has led to significant developments in basic and translational research in the field of tissue engineering. Applied to the esophagus, this concept is based on the in vitro combination of elements judged necessary for in vivo implantation to promote esophageal tissue remodeling. Different methods are currently being explored to develop substitutes using cells, scaffolds, or a combination of both, according to the severity of lesions to be treated. In this review, we discuss recent advances in (1) cell sheet technology for preventing stricture after extended esophageal mucosectomy and (2) full-thickness circumferential esophageal replacement using tissue-engineered substitutes.

Read the article:  Esophageal-tissue-engineering-from-bench-to-bedside

Lousineh Arakelian,1,2 Nobuo Kanai,3,4 Kulwinder Dua,5 Marlène Durand,6,7 Pierre Cattan,1,2,8
and Takeshi Ohki 3,4

1 Cell Therapy Unit, AP-HP, Saint-Louis Hospital, Paris Diderot University, Paris, France.
2 INSERM, Clinical Investigation Center
in Biotherapies (CBT-501) and U1160, Institut Universitaire d’H´ematologie, Saint-Louis Hospital, Paris, France.
3 Department of Surgery, Institute of Gastroenterology, Tokyo Women’s Medical University, Tokyo, Japan.
4 Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan.
5 Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin.
6 University of Bordeaux, CHU Bordeaux, CIC1401 Inserm, Bordeaux, France.
7 Inserm, Bioingénierie Tissulaire, U1026, Bordeaux, France.
8 Department of Digestive and Endocrine Surgery, AP-HP, Saint-Louis Hospital, Paris Diderot University, Paris, France

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